Selective sweeps and parallel mutation in the adaptive recovery from deleterious mutation in Caenorhabditis elegans
نویسندگان
چکیده
منابع مشابه
Purging Deleterious Mutations under Self Fertilization: Paradoxical Recovery in Fitness with Increasing Mutation Rate in Caenorhabditis elegans
BACKGROUND The accumulation of deleterious mutations can drastically reduce population mean fitness. Self-fertilization is thought to be an effective means of purging deleterious mutations. However, widespread linkage disequilibrium generated and maintained by self-fertilization is predicted to reduce the efficacy of purging when mutations are present at multiple loci. METHODOLOGY/PRINCIPAL F...
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Little is known about the role of transposable element (TE) insertion in the production of mutations with mild effects on fitness, the class of mutations thought to be central to the evolution of many basic features of natural populations. We propagated mutation-accumulation (MA) lines of two RNAi-deficient strains of Caenorhabditis elegans that exhibit germline transposition. We show here that...
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An understanding of the forces that contribute to the phylogenetically widespread phenomenon of sexual reproduction has posed a longstanding problem in evolutionary biology. Mutational theories contend that sex can be maintained when the deleterious mutation rate is sufficiently high, although empirical evidence is equivocal and experimental studies are rare. To test the influence of mutation o...
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ISHER (1928) put forward a theory of dominance that is still the subject of Fcontroversy. If a deleterious mutation is continually occurring, it will appear mainly as a heterozygote. FISHER suggested that the fittest of these heterozygotes would be selected and ultimately become as fit as the wild type. The wild type would then be dominant to the deleterious mutation. The fitness of the heteroz...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2010
ISSN: 1088-9051
DOI: 10.1101/gr.108191.110